The Neo-TAXIS Study Team would like to assess the feasibility of opening the Neo-TAXIS study in the UK.
Neo-TAXIS is the UK arm of the international TAXIS randomised trial, and will investigate whether it is possible to avoid an axillary node clearance in node positive patients having neoadjuvant chemotherapy who do not have a complete pathological response in the axilla following completion of treatment.
Neo-TAXIS will randomise patients who do not have a complete pathological response in the axilla to standard care (axillary clearance) or targeted axillary dissection (removal of abnormal/clipped nodes + sentinel node biopsy) followed by nodal radiotherapy. The primary outcome will be disease free survival. Secondary outcomes include quality of life and lymphoedema.
They would therefore like to understand the current management of node positive patients having neoadjuvant chemotherapy and what happens to them following completion of systemic treatment.
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