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Access guidance, webcasts and publications with commentaries using the ABS Information Hub. Search by classification or using keywords.

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Abemaciclib plus endocrine therapy for hormone receptor-positive, HER2-negative, node-positive, high-risk early breast cancer (monarchE): results from a preplanned interim analysis of a randomised, open-label, phase 3 trial

MonarchE is an open-label, randomised, phase 3 trial which recruited high risk hormone receptor positive, HER2 receptor negative, node-positive breast cancer patients (n=5637). Patients were randomise...

Prof Stephen R D Johnston, MD et al | The Lancet Oncology

06.12.2022 | Added: 06.12.2022

Classifications: Adjuvant & Neoadjuvant Treatment

Keywords: Adjuvant treatment Endocrine therapy Trials

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Primary radiotherapy and deep inferior epigastric perforator flap reconstruction for patients with breast cancer (PRADA): a multicentre, prospective, non-randomised, feasibility study

Thiruchelvam et al have recently reported on their study, PRADA, to explore the feasibility of preoperative radiotherapy followed by skin-sparing mastectomy and deep inferior epigastric perforator (DI...

Paul T R Thiruchelvam et al | The Lancet Oncology

07.04.2022 | Added: 07.04.2022

Classifications: Breast & Oncoplastic Surgery

Keywords: Flaps Radiotherapy Breast Reconstruction

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Clinical and molecular characteristics of HER2-low-positive breast cancer: pooled analysis of individual patient data from four prospective, neoadjuvant clinical trials

This pooled analysis of 2310 patients from four neoadjuvant clinical trials examined survival and treatment response in patients with HER2-low-positive (immunohistochemistry 1+ or 2+/in-situ hybridisa...

Prof Carsten Denkert et al | The Lancet Oncology

09.07.2021 | Added: 09.07.2021

Classifications: Breast Cancer Treatment

Keywords: HER2 Positive

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Intraoperative irradiation for early breast cancer (ELIOT): long-term recurrence and survival outcomes from a single-centre, randomised, phase 3 equivalence trial

This study aimed to examine the planned long-term recurrence and survival outcomes from the ELIOT trial. Eligible women, aged 48-75 years with a clinical diagnosis of a unicentric breast carcinoma wit...

Prof Roberto Orecchia et al | The Lancet Oncology

01.05.2021 | Added: 01.05.2021

Classifications: Adjuvant & Neoadjuvant Treatment

Keywords: Trials Intraoperative Radiotherapy

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Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study

Young patients with breast cancer and BRCA mutation have similar survival to sporadic breast cancer patients (POSH trial)

Ellen R Copson et al | The Lancet Oncology

19.02.2018 | Added: 19.02.2018

Classifications: Breast Cancer Risk

Keywords: BRCA Management of the younger patient

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