Outcomes after breast-conserving surgery or mastectomy in patients with triple-negative breast cancer: meta-analysis

This meta-analysis, including 14 studies (n=19819), evaluates the safety of breast conserving surgery (BCS) in triple negative breast cancer. 9828 patients underwent BCS (49.6%) and 9991 patients (50.4%) underwent mastectomy. The pooled odds ratio (OR) for locoregional recurrence was 0.64 (0.48 to 0.85; p=0.002) indicating lower odds for LRR for women who had BCS as opposed to mastectomy.  The pooled OR for distant metastasis was 0.7 (0.53 to 0.94; p=0.02) indicating lower odds of distant metastasis for women who underwent BCS. This difference diminished with follow up time. Pooled hazard ratio of 0.78 (0.69 to 0.89; p<0.001) showed lower hazard ratio for all-cause mortality among women treated with BCS.

Classifications: Breast & Oncoplastic Surgery

Keywords: Breast Conserving Surgery Mastectomy Triple Negative Breast Cancer